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TranscriptomicsTargeting Group3 Medulloblastoma by the anti-PRUNE-1 and anti-LSD1- KDM1A molecules augments their potential therapeutic value.
The combination of AA7.1 and SP2577 affects neuronal commitment,leukocyte differentiation and mitochondrial metabolism. To better dissect the mechanisms of action of these two drugs and to investigate the genes and pathways affected we treated primary Group3 MB for 24 hours with 100μM AA7.1 (prunei...
ORGANISM(S): Homo sapiens 
2024-03-30 | E-MTAB-13616 | biostudies-arrayexpress
TranscriptomicsRNAseq analyses in HEK293T-ACE2 cells infected with SARS-CoV-2 (VOC Delta, 24hours) vs untreated cells
In this study a gene expression (i.e., RNAseq) analysis was performed in HEK293T-ACE2 cellular model upon infection with viral particle belonging to VOC Delta (MOI: 0.026) for 24 hours in order to have a global picture of the transcriptome landscape in response to early phase of infection of SARS-Co...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-11973 | biostudies-arrayexpress
ProteomicsTargeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication.
De Antonellis et al. shows the importance of the Ca2+ channel pump ATP2B1 in the regulation of intracellular Ca2+ levels that positively influence SARS-CoV-2 replication in human cells. Our study identifies the mechanism of action of SARS-CoV-2 in the regulation of the expression of ATP2B1 and ATP2A...
ORGANISM(S): Homo sapiens (Human) 
2024-05-17 | PXD051059 | Pride
Pi3k/akt Sars-cov-2 Atp2a1 Atp2b1 Ca2+ Forkhead box (fox) transcription factor Endoplasmic reticulum 
UnknownCytogenetic prognostication within medulloblastoma subgroups.
Not available
S-EPMC3948094 | biostudies-literature
TranscriptomicsmRNA expression data from primary untreated neuroblastoma tumour samples
The miR-17-92 microRNA cluster is often activated in cancer cells, but the identity of its targets remains largely elusive. Here we examined the effects of activation of the entire miR-17-92 cluster on global protein expression in neuroblastoma cells. In this dataset we deposit global mRNA expressio...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-21713 | biostudies-arrayexpress
TranscriptomicsTargeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication
RNA-seq of human cells Edited using CRISPR vs parental and Unedited control. We identified a rare homozygous intronic variant in the ATP2B1 locus (rs111337717; chr12:89643729, T>C) that is associated with the severity of COVID-19 (i.e., symptomatic versus asymptomatic patients). Next, we employed ...
ORGANISM(S): Homo sapiens 
2024-05-13 | E-MTAB-13916 | biostudies-arrayexpress
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