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ProteomicsIdentification of bacterial secretins
Cyanobacteria and myxobacteria exhibit gliding motility that is associated with the secretion of an exopolymeric slime through nozzle-like structures. Using a combination of biochemical and structural approaches, we demonstrate that these nozzles are composed of secretins belonging to the PilQ/GspD ...
ORGANISM(S): Kamptonema sp. PCC 6506 Myxococcus xanthus DK 1622 Arthrospira platensis NIES-39 
2025-09-29 | PXD066729 | Pride
Secretion Secretin Cyanobacteria Myxobacteria Carbohydrate 
TranscriptomicsRNA-seq of human breast cancer cell line MDA-MB-231 treated with T025 against untreated controls
Deep RNA sequencing was performed to investigate the impact of CLKs inhibitor, T-025, on RNA splicing in triple-negative breast cancer cell lines. A total of 30 million MDA-MB-231 cells were seeded in a 6-well plate. The following day, cells were treated with 1 µM T-025 or 0.1% DMSO as negative cont...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-14664 | biostudies-arrayexpress
TranscriptomicsExposure of C. elegans to AOBr-containing surface water samples and to a M. aeruginosa batch culture
Elevated levels of adsorbable organic bromine compounds (AOBr) have been detected in German lakes, and cyanobacteria like Microcystis, which are known for the synthesis of microcystins, are one of the main producers of natural organobromines. However, very little is known about how environmental rea...
ORGANISM(S): Caenorhabditis elegans 
2015-05-12 | E-GEOD-68709 | biostudies-arrayexpress
TranscriptomicsHigh-fat diet induced gene expression changes in mouse retina may be prevented by introducing bilberries in diet
Obesity and diabetes associated visual impairment and vascular dysfunctions are increasing reasons for vision loss. The detailed mechanisms in these diseases are still largely unknown, but mice models have been useful to study these mechanisms and explore the detailed effects of potential compounds....
ORGANISM(S): Mus musculus 
2012-09-08 | E-GEOD-34154 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [RVPC3_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53465 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_DAC]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53466 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes [TC1A9_IFN]
Reversible MHC class I deficiency on tumour cells is commonly caused by coordinated silencing of antigen-presenting machinery genes and restorable by IFNM-NM-3. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions located in the MHC geno...
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53467 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulations in the IFNM-NM-3 signalling pathway: IFNM-NM-3-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-12-08 | E-GEOD-53469 | biostudies-arrayexpress
TranscriptomicsThe Time-Series Transcriptomic Responses of THP-1 Cells to W-Beijing M. tuberculosis Strains of different sublineages
We report a whole-genome expression profiling of PMA-treated THP-1 human macrophages as a host system, infected by W-Beijing strains of different sublineages or the H37Rv reference strain. Surprisingly, we found that host transcriptional responses were irrespective of inter-sublineage variations. Ba...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-29628 | biostudies-arrayexpress
GenomicsWhole genome sequencing of spontaneous resistant mutants of Mycobacterium tuberculosis H37Rv selectec in the presence of BVL3572S and amino acids
M. tuberculosis H37Rv cultures were exposed to BVL3572S in the absence or presence of L-histidine or L-alanine for at least 4 weeks. Individual colonies were picked and their genomic DNA extracted, indexed, and sequenced.
ORGANISM(S): Mycobacterium tuberculosis 
2026-06-03 | E-MTAB-17255 | biostudies-arrayexpress
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