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ProteomicsDiscovery and characterization of ZUFSP, a novel DUB class important for genome stability
Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal structures of ZUFSP in complex with ubiquitin reveal several distinctive features of ubiquitin recognition and cataly...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD008509 | Pride
Ubiquitin binding domain Deubiquitinase Dna damage 
ProteomicsA family of unconventional deubiquitinases with modular chain specificity determinants
Interactors of human ZUFSP in HEK-293T cells. Flp-in T-REx 293 cells with stable 3xFLAG-ZUFSP integration were assayed for ZUFSP interactors under three different conditions: i) Cells expressing wild-type ZUFSP, ii) Cells expressing catalytically inactive ZUFSP, iii) Cells expressing wild-type ZUFSP...
ORGANISM(S): Homo sapiens (Human) 
2018-04-06 | PXD008731 | Pride
Human Hek-293t cells Zufsp 
GenomicsmRNA-seq of wild-type or ZUFSP knockout THP1 cells after vesicular stomatitis virus infection
mRNA-seq of wild-type or ZUFSP knockout THP1 cells after vesicular stomatitis virus infection
PRJNA1000962 | ENA
TranscriptomicsmRNA-seq of wild-type or ZUFSP knockout THP1 cells after vesicular stomatitis virus infection
To investigate the function of ZUFSP in immune response, we established ZUFSP knockout cell lines in which ZUFSP gene has been knockdown by sgRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of WT or ZUFSP knockdown THP1 cells with or without VSV infection
ORGANISM(S): Homo sapiens 
2024-10-01 | GSE239783 | GEO
UnknownDiscovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.
Not available
S-EPMC5896202 | biostudies-literature
UnknownA structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family.
Not available
S-EPMC8776766 | biostudies-literature
UnknownA family of unconventional deubiquitinases with modular chain specificity determinants.
Not available
S-EPMC5824887 | biostudies-literature
UnknownReactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.
Not available
S-EPMC5862848 | biostudies-literature
UnknownRead-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma.
Not available
S-EPMC5053695 | biostudies-literature
ProteomicsHewings et al. 2018
raw data files associated with manuscript titled "Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes". Result file includes all PSMs identified in the experiment after performing necessary quality filter.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-25 | MSV000081972 | MassIVE
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