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ProteomicsH3K4 methylation-promoted transcriptional memory supports faithful zygotic genome activation and development
Accurately established transcriptional programs are paramount for successful embryonic development. At zygotic genome activation, gene expression is initiated for the first time in the life of an embryo. Pioneer transcription factors present in the embryo are essential for this process, however, the...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-11-25 | PXD058937 | Pride
H3k4me3  zygotic genome activation (zga)  epigenetic memory  chromatin  transcriptional memory  transcription  early development  xenopus 
ProteomicsQuantitative proteomics reveals the dynamic proteome landscape of zebrafish embryos during maternal-to-zygotic transition and its relationship to zygotic genome activation
Upon fertilization, the embryonic genome remains transcriptionally inactive until the mid-blastula transition. Zygotic genome activation (ZGA) of vertebrate embryos has been extensively studied using nucleic acid-based strategies, but proteomics data are still scarce, impeding the full mechanistic u...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Xenopus laevis (African clawed frog) 
2024-05-01 | PXD036678 | Pride
Zygotic genome activation Zebrafish embryo Maternal-to-zygotic transition Quantitative proteomics 
TranscriptomicsOocyte-expressed Yes-associated Protein (YAP) is a Key Activator of the Early Zygotic Genome in Mouse
We generated maternal and paternal mouse models with Yap1-deletion, and elucidated the function of maternal YAP in zygotic genome activation. RNA sequencing with 2 WT oocyte samples at GV stage, 2 YAP-/- oocyte samples at GV stage, 1 WT embryo samples at 4cell stage, 1 YAP-/- embryo samples at at 4-...
ORGANISM(S): Mus musculus 
2016-02-28 | E-GEOD-74344 | biostudies-arrayexpress
GenomicsZygotic transcription of ZGA staged embryos [GRO-seq]
Zygotic transcription of ZGA staged embryos [GRO-seq]
PRJNA678807 | ENA
UnknownHuman zygotic genome activation is initiated from paternal genome.
Not available
S-EPMC9887001 | biostudies-literature
UnknownThe maternal-zygotic transition and zygotic activation of the Mnemiopsis leidyi genome occurs within the first three cleavage cycles.
Not available
S-EPMC5727576 | biostudies-literature
ProteomicsGENE EXPRESSION DYNAMICS BEFORE AND AFTER ZYGOTIC GENOME ACTIVATION IN DROSOPHILA EARLY EMBRYOGENESIS
Post-transcriptional gene regulatory mechanisms are fundamental for the determination of gene expression dynamics and especially crucial for the earliest stages of animal development in which transcription is nearly silent. Here we performed high-resolution gene expression level change analysis in D...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-09-08 | PXD047784 | Pride
Drosophila Mzt Ubiquitin Rbp 
GenomicsOBOX regulates murine zygotic genome activation and early development
OBOX regulates murine zygotic genome activation and early development
PRJNA890651 | ENA
GenomicsThe Spatiotemporal Control of Zygotic Genome Activation
The Spatiotemporal Control of Zygotic Genome Activation
PRJNA505537 | ENA
UnknownOBOX regulates mouse zygotic genome activation and early development.
Not available
S-EPMC10528489 | biostudies-literature
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