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MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
TranscriptomicsBortezomib resistance in THP-1 cell line
Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the THP-1 monocytic/macrophage cell line. On th...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-11771 | biostudies-arrayexpress
TranscriptomicsEfficacy of bortezomib in a direct xenograft model of primary effusion lymphoma
Primary effusion lymphoma is an aggressive B-cell lymphoma most commonly diagnosed in HIV-positive patients and universally associated with Kaposi’s sarcoma-associated herpesvirus (KSHV). Chemotherapy treatment of PEL yields only short-term remissions in the vast majority of patients yet efforts to ...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-22594 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human samples from multiple myeloma patients treated with bortezomib or dexamethasone
The aims of this study were to assess the feasibility of prospective pharmacogenomics research in multicenter international clinical trials of bortezomib in multiple myeloma and to develop predictive classifiers of response and survival with bortezomib. Patients with relapsed myeloma enrolled in pha...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-9782 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression in response to bortezomib treatment [mouse cell lines II]
Genome-wide analysis of gene expression in response to bortezomib treatment(33 nM) in cell lines before and after selection for resistance. Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of neoplastic plasma cells in the bone marrow. While the first-to-market pr...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-41928 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression in response to bortezomib treatment [mouse cell lines I]
Genome-wide analysis of gene expression in response to bortezomib treatment (33 nM) in cell lines before and after selection for resistance. Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of neoplastic plasma cells in the bone marrow. While the first-to-market p...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-41927 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression in response to bortezomib treatment [human cell lines].
Genome-wide analysis of gene expression in response to bortezomib treatment (33 nM) in cell lines before and after selection for resistance. Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of neoplastic plasma cells in the bone marrow. While the first-to-market p...
ORGANISM(S): Homo sapiens 
2013-07-02 | E-GEOD-41929 | biostudies-arrayexpress
TranscriptomicsBortezomib inhibits mTOR pathway in multiple myeloma cells via induced expression of REDD1.
The combination of bortezomib and dexamethasone should become the reference induction treatment for multiple myeloma patients younger than 65 years. Pharmacogenomic profiles of genes involved in response to treatment may help to understand resistance. We performed gene expression profiling in 9 myel...
ORGANISM(S): Homo sapiens 
2010-02-14 | E-GEOD-11866 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of four human Adult T-cell leukemia (ATL) cell lines treated with proteasome inhibitor, bortezomib
Adult T-cell leukemia (ATL) is a fatal neoplasia derived from HTLV-1 infected T lymphocytes exhibiting constitutive activation of NF-kB. To elucidate the complex molecular mechanism of anti-tumor effect of the proteasome inhibitor, bortezomib in ATL cells, we attempted to perform gene expression pr...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6034 | biostudies-arrayexpress
TranscriptomicsEffect of treatment OPM2 multiple myeloma cells with EPA, DHA or bortezomib
OPM2 cells were seeded in a 12-well plate at density of 10 × 103 cells/well and incubated with the indicated concentrations of compounds. OPM2 cells were treated with 50 µM of DHA/EPA (6 h) or 10 nM of bortezomib (4 h). Total RNA was extracted from cells using RNeasy Mini Kit (74104, Qiagen, Hilden,...
ORGANISM(S): Homo sapiens 
2022-06-26 | E-MTAB-11907 | biostudies-arrayexpress
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