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ProteomicsThrombo-Inflammation in Preeclampsia and Pregnancy Induced Hypertension: Proteomics And Metabolomics Profiling of Platelets and Plasma Mediators
Background: Platelets may be pivotal mediators of the thrombo-haemorrhagic complications of preeclampsia (PE), linking inflammation and thrombosis with endothelial and vascular dysfunction. While gestational hypertension (GH) falls within the spectrum of hypertensive complications of pregnancy and i...
ORGANISM(S): Homo sapiens (Human) 
2022-03-16 | PXD031278 | Pride
Metabolomics String bg Preeclampsia Pregnancy Gestational hypertension Proteomics Pathway analysis Lrrc27/42 
ProteomicsProteomic and Metabolomic Profile of Cognitive Stability and Decline Over an Aerobic Exercise Intervention and 5-years later in Older Adults
. In this study we identify a unique signature protein and metabolic biomarker panel for those who improve in cognition and those who decline, assessed by the Montreal Cognitive Assessment (MoCA). We investigate a discovery cohort of Brain in Motion participants involving a quasi-experimental aerobi...
ORGANISM(S): Homo sapiens (Human) 
2025-04-15 | PXD049430 | Pride
Plasma Metabolomics Exercise Aging Proteomics 
ProteomicsSkin regeneration is enabled in the absence of fibroblast inflammatory priming
Mammalian skin wounds heal by forming fibrotic scars. We report that reindeer antler velvet exhibits regenerative wound healing, whereas identical injury to back skin forms scar. This regenerative capacity was retained following ectopic transplantation of velvet to scar-forming sites. Single-cell mR...
ORGANISM(S): Homo sapiens (Human) 
2023-02-23 | PXD035749 | Pride
Reindeer antler velvet  wound healing  skin regeneration  stromal-immune crosstalk  immune modulation  inflammatory-priming  fibrotic scar  fetal human fibroblasts  myeloid cell maturation  single-cell multi-omics 
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