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TranscriptomicsGene expression profiling of immortalized normal fibroblasts from a breast cancer patient after transient transfection with miR-9 or control.
To clarify the molecular alterations triggered by miR-9 to induce the conversion of breast normal fibroblasts to a CAF-phenotype, gene expression profile of normal fibroblasts transiently transfected with miR-9 or control was performed. We performed a gene expression profiling of immortalized normal...
ORGANISM(S): Homo sapiens 
2016-05-15 | E-GEOD-76996 | biostudies-arrayexpress
TranscriptomicsmiR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy (mRNA)
MicroRNA (miRNA) expression profiling identified miR-638 as one of the most significantly overexpressed miRNAs in metastatic lesions compared with primary melanomas. miR-638 enhanced the tumourigenic properties of melanoma cells in vitro and lung colonization in vivo. mRNA expression profiling of mi...
ORGANISM(S): Homo sapiens 
2014-01-30 | E-GEOD-54493 | biostudies-arrayexpress
TranscriptomicsDownregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype
Currently, multiple myeloma (MM) patients are broadly grouped into a non-hyperdiploid Group (nh-MM), highly enriched for IgH translocations, or into a hyperdiploid Group (h-MM), which is typically characterized by trisomies of some odd-numbered chromosomes. We compared the miRNA expression profiles...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-40308 | biostudies-arrayexpress
TranscriptomicsExpression profiles of HSPCs overexpressing microRNA cluster 99b/let-7e/125a, miR-125a, miR-155 and empty vector.
Hematopoietic stem/progenitor cell (HSPC) traits differ between genetically distinct mouse strains. For example, DBA/2 mice have a higher HSPC frequency compared to C57BL/6 mice. We performed a genetic screen for microRNAs that are differentially expressed between LSK, LS−K+, erythroid and myeloid c...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-33689 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs which bind to YB-1 protein
To assess the direct association of the nucleic acid binding protein yb-1 with mature microRNAs in breast cancer. To do this we performed immunoprecipitation (IP) of YB-1 protein to pull-down linked RNAs Two breast cancer cell-lines, representative of Luminal A and Basal molecular subtypes were used...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-50141 | biostudies-arrayexpress
TranscriptomicsEffects of YB-1 protein reduction on microRNA abundance in breast cancer cell-lines
To assess the association of the nucleic acid binding protein yb-1 with mature microRNAs levels in breast cancer. To do this we performed YB-1 siRNA treatement in triplicates alongside an siRNA control Two breast cancer cell-lines, representative of Luminal A and Basal molecular subtypes were used, ...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-50087 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiles of four developmentally related hematopoietic cell types isolated from the BM of B6 and D2 mice.
performed a genetic screen for microRNAs that are differentially expressed between LSK, LS−K+, erythroid and myeloid cells isolated from C57BL/6 and DBA/2 mice. This analysis identified 131 microRNAs that were differentially expressed between cell types and 15 that were differentially expressed betw...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-33690 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression between skin and cervix induced by the E7 oncoprotein in a transgenic mouse model
HPV16 E7 oncoprotein expression in K14E7 transgenic mice induces cervical cancer after 6 months of treatment with the co-carcinogen 17M-NM-2-estradiol. In untreated mice, E7 also induces skin tumors late in life, albeit at low penetrance. These findings indicate that E7 alters cellular functions in ...
ORGANISM(S): Mus musculus 
2012-06-09 | E-GEOD-36219 | biostudies-arrayexpress
TranscriptomicsGenome-wide mRNA expression profiles induced by infection with the pandemic and seasonal influenza A viruses in macrophages
Infection with pandemic A/H1N1 influenza virus induces high levels of circulating and lung pro-inflammatory cytokines and chemokines in experimental models and humans. These inflammatory mediators contribute to poor clinical outcomes of this infection. To compare the regulation of inflammatory respo...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-36012 | biostudies-arrayexpress
UnknownEvaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Not available
S-EPMC10771257 | biostudies-literature
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