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TranscriptomicsTranscription profiling of human primary gastric tumors (MSI and MSS) and adjacent normal samples
Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without MSI was analysed. Unsupervised analysis showed that the immune and apoptotic gene networks efficiently disc...
ORGANISM(S): Homo sapiens 
2009-01-03 | E-GEOD-13911 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human and dog breast cancers
Spontaneous tumors in dog have been demonstrated to share many features with their human counterparts, including relevant molecular targets, histological appearance, genetics, biological behavior and response to conventional treatments. Mammary tumors in dog therefore provide an attractive alternati...
ORGANISM(S): Canis lupus familiaris 
2010-06-25 | E-GEOD-14999 | biostudies-arrayexpress
GenomicsRetinoic acid signaling constrains the plasticity of Th1 cells and prevents development of pathogenic Th17 cells [ChIP-Seq experiments]
CD4+ T cells differentiate into phenotypically distinct T-helper cells upon antigenic stimulation. Regulation of plasticity between these CD4+ T-cell lineages is critical for immune homeostasis and prevention of autoimmune diseases. However, the factors that regulate lineage stability are largely un...
ORGANISM(S): Mus musculus 
2015-03-10 | E-GEOD-60353 | biostudies-arrayexpress
TranscriptomicsCandidate driver genes in Sѐzary syndrome
Illumina human Omni5Exome arrays were used to investigate CNVs in Sѐzary syndrome tumours as part of a larger study involving whole exome sequencing of the same samples and targeted resequencing of a further cohort. 16 Samples underwent SNP array including 10 tumour/gDNA matched samples that also u...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-80650 | biostudies-arrayexpress
TranscriptomicsmiRNA analysis of triple-negative breast cancers in association with clinical and molecular phenotypes
Background: This study focuses on the analysis of miRNAs expression data in a cohort of 181 well characterised breast cancer samples composed primarily of triple-negative (ER/PR/HER2-negative) tumours with associated genome-wide DNA and mRNA data, extensive patient follow-up and pathological informa...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-40267 | biostudies-arrayexpress
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