mrc-5 - OmicsDI

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Organisms

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Repository

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Tissue

Cell culture (11)
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Disease free (3)
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Multi-pathological condition. According with Working Group of the Sociedad Española de Medicina Interna (SEMI), a patients are defined as multi-pathological or polypathological when they have chronic diseases that belong to two or more of the eight next categories:-Category A: NYHA heart failure class II (slight limitation of physical activity, in which ordinary physical activity causes dyspnea, angina, fatigue or palpitations). Ischemic heart disease.- Category B: Vasculitis and systemic autoimmune diseases. Chronic kidney disease defined by elevated creatinine (>1.4 mg/dL in men or >1.3 mg/dL in women) or proteinuria (albumin/creatinine ratio >300 mg/g, microalbuminuria >3mg/dL in urine sample or albumin >300 mg/day in 24-hour urine, for 3 months).- Category C: Chronic respiratory disease classified as MCR grade 2 (unable to keep the pace of another person of the same age (1)
Alveolar rhabdomyosarcoma (1)
Celiac disease (1)
Embryonal rhabdomyosarcoma (1)
Herpes simplex (1)
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Mass Spectrometry (35)
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Instrument Platform

Illumina NovaSeq 6000 (16)
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Single cells were captured using the 10x Genomics Chromium Controller. (2)
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Bruker (2)
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CHEBI ID

CHEBI:15366 (5)
CHEBI:16919 (5)
CHEBI:30751 (4)
CHEBI:17268 (4)
CHEBI:422 (4)
CHEBI:16737 (4)
CHEBI:17191 (4)
CHEBI:30769 (4)
CHEBI:16856 (3)
CHEBI:16977 (3)
CHEBI:15428 (3)
CHEBI:15891 (3)
CHEBI:18050 (3)
CHEBI:18012 (3)
CHEBI:32816 (3)
CHEBI:16414 (3)
CHEBI:15354 (3)
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CHEBI:17895 (3)
CHEBI:17295 (3)
CHEBI:8572 (2)
CHEBI:18139 (2)
CHEBI:70959 (2)
CHEBI:70958 (2)
CHEBI:64850 (2)
CHEBI:17634 (2)
CHEBI:18066 (2)
CHEBI:35704 (2)
CHEBI:17200 (2)
CHEBI:60645 (2)

Metabolite Name

L-Alanine (5)
Glutathione (5)
L-Threonine (5)
Choline (5)
Taurine (5)
L-Glutamine (5)
L-Serine (5)
L-Valine (5)
L-Isoleucine (5)
L-Leucine (5)
L-Phenylalanine (5)
D-Glucose (4)
Glycine (4)
Formic acid (4)
Adenosine triphosphate (4)
Guanosine triphosphate (4)
Myoinositol (4)
Isopropyl alcohol (4)
Unknown (4)
L-Aspartic acid (4)
Acetic acid (4)
Acetone (4)
ADP (4)
NADP (4)
NAD (4)
L-Glutamic acid (4)
Phosphorylcholine (4)
Creatine (4)
Ethanol (3)
L-Lactic acid (3)

First Public Date

2014 (27)
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2023 (6)
2017 (6)
2016 (5)
2020 (4)
2019 (4)
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2022 (3)
2018 (3)
2015 (3)
2013 (2)
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Modelling Approach

Mathematical model (1)

Study status

Not yet recruiting (1)

Lab affiliation

Department of Molecular Biology, Princeton University (2)
Philip Morris R&D, Neuchatel, Switzerland (2)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (2)
1) Medizinisches Proteom-Center, Ruhr-Universität Bochum, Universitätsstraße 150, 44801 Bochum, Germany 2) Institute of Virology, University Hospital, University Duisburg-Essen, Hufelandstr. 55, 45120 Essen, Germany (1)
1. MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK. 2. Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK. (1)
Biotechnology and Bioengineering Center, Deptartment of Microbiology, Medical College of Wisconsin (1)
Center for Proteomics and Metabolomics, Leiden University Medical Center (1)
Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK (1)
DIVAS (1)
DIVAS, Department of Veterinary Medicine and Animal Sciences (1)
Department of Microbiology & Immunology UNC School of Medicine UNC-Chapel Hill (1)
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (1)
Department of Pharmacology, Soochow University (1)
Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China (1)
Discovery Proteomics Facility Target Discovery Institute University of Oxford (1)
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland (1)
Dundee University, School of Life Sciences (1)
Head of The Steen-Laboratory, Director of Proteomics, Boston Children's Hospital, Harvard Medical School (1)
Institute of Chemistry, Slovak Academy of Sciences (1)
Institute of Medical Virology, University of Zurich, Switzerland (1)
Institute of Molecular Systems Biology, ETH Zurich (1)
MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK. Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK. (1)
MRC Protein Phosphorylation and Ubiquitylation Unit (PPU), School of Life Sciences, University of Dundee, Dundee, United Kingdom. (1)
MRC Protein Phosphorylation and Ubiquitylation Unit, The Sir James Black Centre, University of Dundee, United Kingdom (1)
Mass Spectrometry Facility Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ (1)
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit School of Life Sciences, University of Dundee, Dundee, Scotland (1)
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland (1)
University of Bristol (1)
University of Dundee (1)
University of Dundee, School of Life Sciences (1)

IsPrivate

False (1)

Classification

viruses (1)
protozoa (1)
bacteria (1)

Study type

Transcription profiling by array (102)
RNA-seq of coding RNA (18)
RNA-seq of coding RNA from single cells (14)
RNA-seq of non coding RNA (8)
ChIP-chip by array (4)
ScATAC-seq (4)
Methylation profiling by array (4)
ChIP-chip by tiling array (3)
Animal - High-throughput sequencing (3)
ChIP-seq (3)
Unknown experiment type (2)
Comparative genomic hybridization by array (2)
Methylation profiling by high throughput sequencing (2)
RNA-seq of total RNA (2)
Transcription profiling by SAGE (1)
Cell line - High-throughput sequencing (1)
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CLIP-seq (1)
Spatial transcriptomics by high-throughput sequencing (1)
Other (1)
Single nucleus RNA sequencing (1)
CUT&RUN (1)
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Release Date

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2008 (18)
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2006 (2)
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2003 (2)
2000 (2)
2002 (1)
2001 (1)

Location

Colombia (1)

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RNA-seq of young and quiescent MRC-5 human fibroblasts

Quiescent MRC-5 fibroblasts were compared to young fibroblasts 6 samples: 3 biological replicates for each age group: young and quiescent MRC-5 cells. 50bp, single-end reads, no strand-specific reads

ORGANISM(S): Homo sapiens

2014-11-06 | E-GEOD-60883 | biostudies-arrayexpress

Microarray analysis of MRC-5 cells infected with Zika virus strains

To better understand the critical drivers of Zika virus pathogenicity, we used microarray analysis to evaluate the host responses triggered by Zika virus infection in MRC-5 cells.

ORGANISM(S): Homo sapiens

2021-03-23 | E-MTAB-10292 | biostudies-arrayexpress

Mesenchymal stem cells-derived exosomes and MRC-5 cell-derived exosomes LC-MSMS

We compared the differential proteins between Mesenchymal stem cells-derived exosomes MRC-5 cell-derived exosomes.

ORGANISM(S): Homo sapiens (Human)

2024-05-21 | PXD033839 | Pride

RNA-seq of young and quiescent (9 days) MRC-5 human fibroblasts

PRJNA486494 | ENA

RNA-seq of young and quiescent (9 days) MRC-5 human fibroblasts

Comparison of gene expression profiles of quiescent MRC-5 fibroblasts and young MRC-5 fibroblasts. Jena Centre for Systems Biology of Ageing – JenAge (www.jenage.de)

ORGANISM(S): Homo sapiens

2021-10-19 | GSE118693 | GEO

Homo sapiens strain:MRC-5

ChIP-seq profiling of H4K12 lactylation in human lung fibroblasts

PRJNA1414858 | ENA

RNA-seq of young and quiescent MRC-5 human fibroblasts

Quiescent MRC-5 fibroblasts were compared to young fibroblasts Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

ORGANISM(S): Homo sapiens

2014-11-06 | GSE60883 | GEO

Iron chelation on human cytomegalovirus infected MRC-5 fibroblasts

MRC-5 cells (American Type Culture Collection, Manassas, VA) derived from human lung fibroblasts (passages 19-25) were cultured in MEM with Earle’s salts, supplemented with 2 mM glutamine and 10% heat-inactivated FCS. Cells were grown in an incubator with a humidified atmosphere of 5% CO2 in air at ...

ORGANISM(S): Homo sapiens

2003-09-20 | GSE672 | GEO

miRNA sequencing of Mesenchymal stem cells-derived exosomes and MRC-5 cell-derived exosomes

PRJNA863244 | ENA

Sequencing of HFF and MRC-5 human fibroblast treated with BFA and FLI-06

PRJNA483212 | ENA

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