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MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
TranscriptomicsGenome-wide microRNA analysis of NPC and non-NPC specimens gene expression
Analysis of differential expression between NPC and non-NPC tissues at miRNA expression level. We used a miRNA microarray platform to investigate the profile between NPC tissues and normal nasopharyngeal tissues to evaluate the relationship between miRNA expression and NPC. Recognition of the aberr...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-22587 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of microRNAs in NPC FFPE tissue samples
Nasopharyngeal carcinoma (NPC) is a challenging cancer that is rare in the United States but shows exceptionally high incidence in Southern China, Indonesia, and Malaysia. While the hallmark of NPC is striking geographic variation, early detection and clinical management are also critical characteri...
ORGANISM(S): Homo sapiens 
2014-01-13 | E-GEOD-46172 | biostudies-arrayexpress
TranscriptomicsNESG1-mediated differential expression genes in nasopharyngeal carcinoma (NPC)
Analysis of differential expression genes in NESG1-overexpressed and negative nasopharyngeal carcinoma. NESG1 is a candidate tumor suppressor in NPC. Results provide insight into the molecular pathogenesis of NESG1 in NPC. NESG1 cDNA was transfected into NESG1-negative NPC 5-8F cells and affymetrix ...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-27318 | biostudies-arrayexpress
GenomicsZrf1 is required to establish and maintain neural progenitor identity (ChIP-Seq)
We report ChIP-seq data for Zrf1 and Ring1B occupancy in NPC Examination and comparison of DNA binding profile of Zrf1 and Ring1B in NPC
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-53540 | biostudies-arrayexpress
ProteomicsLabel-Free Quantitative Proteomics Data for NPC Permeability Barrier Dynamics
This dataset contains label-free quantitative (LFQ) mass spectrometry analyses of proteins associated with affinity-purified isolated native Saccharomyces cerevisiae nuclear pore complexes (NPCs). The study compared wild type NPCs (+CP WT NPCs) with NPCs frozen at -80°C, or incubate in buffer at 4°C...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-10-06 | PXD069104 | Pride
Npc Central transporter Lfq 
TranscriptomicscDNA microarray analysis of miR-1 transfected HeLa and NPC-TW01 cells
To investigate the mechanisms of miR-1 inducing apoptosis, we performed cDNA expression microarray analysis to identify the candidate miR-1 regulating genes that are involved in apoptosis. NPC-TW01 cells were transfected with miR-1 or miR-negative control for 40 hours, their total RNA were isolated ...
ORGANISM(S): Homo sapiens 
2011-04-13 | E-GEOD-28522 | biostudies-arrayexpress
TranscriptomicsMouse high grade astrocytoma cells (GL261) treated with neural stem/precursor cell (NPC) conditioned medium or non-conditioned medium (control)
Primary astrocytomas of high histopathological grade (HG-astrocytomas) are largely restricted to older patients and are almost invariably fatal despite multimodal therapy. Here, we show that the young brain has an endogenous defense mechanisms against HG-astrocytomas. Neural precursor cells (NPCs) m...
ORGANISM(S): Mus musculus 
2012-04-30 | E-GEOD-37671 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of nasopharyngeal carcinoma model system (miRNA)
Nasopharyngeal carcinoma (NPC) is a prevalent malignancyt disease in Southeast Asia among the Chinese population. Aberrant regulation of transcripts has been implicated in many types of cancers including NPC. Herein, we characterized mRNA and miRNA transcriptomes by RNA sequencing (RNASeq) of NPC mo...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-54161 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of nasopharyngeal carcinoma model system (mRNA)
Nasopharyngeal carcinoma (NPC) is a prevalent malignancyt disease in Southeast Asia among the Chinese population. Aberrant regulation of transcripts has been implicated in many types of cancers including NPC. Herein, we characterized mRNA and miRNA transcriptomes by RNA sequencing (RNASeq) of NPC mo...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-54159 | biostudies-arrayexpress
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