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ProteomicsHigh-salt diet promotes hypertrophic scarring through TRPC3-mediated mitochondrial Ca2+ homeostasis dysfunction
Diet High in salt content have been associated with cardiovascular disease and chronic inflammation. We recently demonstrated that transient receptor potential canonical 3 (TRPC3) channels regulate myofibroblast transdifferentiation in hypertrophic scars. Here, we examined how high salt activation o...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD042087 | Pride
High salt hypertrophic scar trpc3 
TranscriptomicsDeep Transcriptomic Profiling Of M1 Macrophages Lacking Trpc3
Previous studies from our laboratory using mice with macrophage-specific loss of Trpc3 function revealed a significant, selective effect of Trpc3 in the biology of M1, or inflammatory macrophages. Whereas the activation of some components of the unfolded protein response and the pro-apoptotic mediat...
ORGANISM(S): Mus musculus 
2017-12-30 | GSE87478 | GEO
GenomicsPyrazole-derived TRPC3 antagonist ameliorates synaptic dysfunctions and memory deficits in Alzheimer’s disease models
Pyrazole-derived TRPC3 antagonist ameliorates synaptic dysfunctions and memory deficits in Alzheimer’s disease models
PRJNA1065917 | ENA
TranscriptomicsPyrazole-derived TRPC3 antagonist ameliorates synaptic dysfunctions and memory deficits in Alzheimer’s disease models
Among the canonical transient receptor potential (TRPC) channels, TRPC3 expression is uniquely upregulated in brains with Alzheimer’s disease (AD) based on our recent studies. Herein, we used JW-65, a selective inhibitor for TRPC3 over TRPC6, to investigate the potentially distinct role of TRPC3 in ...
ORGANISM(S): Mus musculus 
2025-07-17 | GSE253510 | GEO
TranscriptomicsTRPC3 Contributes to Cyclophosphamide-Induced Cystitis Progression by Enhancing Bladder Fibrosis Through Activation of the TGF-β/Smad Pathway
The pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS) remains incompletely understood. Bladder fibrosis is a significant histopathological feature of IC/BPS, particularly in non-Hunner-type IC (NHIC). Transient receptor potential cation channel subfamily C member 3 (TRPC3) is know...
ORGANISM(S): Rattus norvegicus 
2025-03-31 | GSE293339 | GEO
GenomicsTRPC3 Contributes to Cyclophosphamide-Induced Cystitis Progression by Enhancing Bladder Fibrosis Through Activation of the TGF-β/Smad Pathway
TRPC3 Contributes to Cyclophosphamide-Induced Cystitis Progression by Enhancing Bladder Fibrosis Through Activation of the TGF-β/Smad Pathway
PRJNA1244149 | ENA
GenomicsMus musculus
Deep Transcriptomic Profiling Of M1 Macrophages Lacking Trpc3
PRJNA344886 | ENA
UnknownTRPC3 Regulates Islet Beta-Cell Insulin Secretion.
Not available
S-EPMC9951314 | biostudies-literature
UnknownTRPC3 Regulates the Proliferation and Apoptosis Resistance of Triple Negative Breast Cancer Cells through the TRPC3/RASA4/MAPK Pathway.
Not available
S-EPMC6520729 | biostudies-literature
UnknownThe transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin.
Not available
S-EPMC3162424 | biostudies-literature
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