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ProteomicsMemory CD8+ T cells upregulate glycolysis and effector functions under limiting oxygen conditions
Memory CD8+ T cells are indispensable for maintaining long-term immunity against intracellular pathogens and tumors. Despite their presence in oxygen-deprived tissues of infection sites or tumors, the impact of local oxygen pressure on memory CD8+ T cells has remained largely unclear. We sought to e...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-01 | PXD032236 | Pride
Cytotoxic t cells Cd8+ memory t cells Physioxic cell culture Tcr-mediated activation T cell metabolism 
ProteomicsTissue-resident memory T cells maintain identity after in vitro restimulation
Resident memory T (TRM) cells have been recently established as an important subset of memory cells that provide early and essential protection against reinfection in the absence of circulating memory T cells. Recent findings showing that TRM expand in vivo after repeated antigenic stimulation indic...
ORGANISM(S): Mus musculus (Mouse) Listeria monocytogenes 
2025-09-30 | PXD041211 | Pride
Cd8+ memory t cells Tissue-resident memory t cells T cell metabolism Hypoxic t cell cultures 
UnknownBimD/SPO76 is at the interface of cell cycle progression, chromosome morphogenesis, and recombination.
Not available
S-EPMC33457 | biostudies-literature
ProteomicsIdentification of different human CD8 T cell subsets by superior cytotoxicity in human T cells
Cytotoxic CD8+ T cells can effectively kill target cells by producing cytokines, chemokines and granzymes. Expression of these effector molecules is however highly divergent, and tools that identify and pre-select potent killer cells are lacking. Human CD8+ T cells can be divided into IFNGand IL-2 p...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012874 | Pride
Human Il2 Ifng Cd8 T cells 
ProteomicsLabel-free analysis of CD8+ T cell subset proteomes supports a progressive differentiation model of virus-specific T cells in humans
Different pathogens trigger naïve T cells to express distinct sets of effector proteins. To better understand the molecular mechanisms that drive this functional specification, we used high resolution, label-free mass spectrometry to measure proteomic differences between the seven largest circulatin...
ORGANISM(S): Homo sapiens (Human) 
2017-05-02 | PXD004637 | Pride
Human Cd8+ t cells 
UnknownBiomarkers in Exhaled Breath Condensate Are Not Predictive for Pulmonary Exacerbations in Children with Cystic Fibrosis: Results of a One-Year Observational Study.
Not available
S-EPMC4822839 | biostudies-literature
UnknownA one-year pilot study comparing direct-infusion high resolution mass spectrometry based untargeted metabolomics to targeted diagnostic screening for inherited metabolic diseases.
Not available
S-EPMC10657655 | biostudies-literature
UnknownSARS-CoV-2-specific B cell responses in non-draining lymph nodes and antibody functionalities in immunized end-stage renal disease patients.
Not available
S-EPMC12722218 | biostudies-literature
UnknownDesign of an RCT on cost-effectiveness of group schema therapy versus individual schema therapy for patients with Cluster-C personality disorder: the QUEST-CLC study protocol.
Not available
S-EPMC9548126 | biostudies-literature
UnknownIdentification of human D lactate dehydrogenase deficiency.
Not available
S-EPMC6443703 | biostudies-literature
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