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TranscriptomicsSpecific modulation of mucosal immune response, tolerance and proliferation in mice colonized with A. muciniphila
Epithelial cells of the mammalian intestine are covered with a mucus layer that prevents direct contact with intestinal microbes but also constitutes a substrate for mucus-degrading bacteria. To study the effect of mucus degradation on the host response, germ-free mice were colonized with Akkermansi...
ORGANISM(S): Mus musculus 
2011-09-20 | E-GEOD-18587 | biostudies-arrayexpress
TranscriptomicsIdentification of the core gene-regulatory network that governs the dynamic adaptation of intestinal homeostasis during conventionalization in mice
Molecular adaptation of the intestinal mucosa occurs during microbial conventionalization to maintain a balanced immune response. However, the genetic regulation of such adaptation is obscure. Here, combined analysis of germ free and conventionalized mice revealed that the major molecular adaptation...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-32513 | biostudies-arrayexpress
TranscriptomicsCarbohydrates Regulate Virulence Gene Expression in Streptococcus suis
Streptococcus suis is a major pig pathogen as well as an emerging zoonotic pathogen. Previous work has demonstrated that the S. suis extracellular amylopullulanase enzyme (ApuA) that degrades {alpha}-glucans also functions as an adhesin for porcine epithelial cells. To identify the mechanisms linkin...
ORGANISM(S): Streptococcus suis P1/7 
2014-03-18 | E-GEOD-40658 | biostudies-arrayexpress
TranscriptomicsMucosal responses of healthy humans to three different probiotic Lactobacillus bacteria
Probiotic bacteria, specific representatives of bacterial species that are a common part of the human microbiota, are proposed to deliver health benefits to the consumer by modulation of intestinal function via largely unknown molecular mechanisms. To explore in vivo mucosal responses of healthy adu...
ORGANISM(S): Homo sapiens 
2010-09-08 | E-GEOD-18741 | biostudies-arrayexpress
TranscriptomicsMucosal responses of healthy humans to exponentially growing or stationary Lactobacillus plantarum bacteria
Some commensal bacteria stimulate the immune system but do not present specific antigenicity. Such adjuvant effects have been reported for the bacterial species Lactobacillus plantarum. To study in vivo human responses to L. plantarum, a randomised double-blind placebo-controlled cross-over study wa...
ORGANISM(S): Homo sapiens 
2009-01-20 | E-GEOD-11355 | biostudies-arrayexpress
MetabolomicsExploring the Interspecific Interactions and the Metabolome of the Soil Isolate Hylemonella gracilis
Analysis of aquatic microbial communities revealed that parts of its diversity consist of bacteria with cell sizes of ~0.1 μm. Such bacteria can show genomic reductions and metabolic dependencies with other bacteria. So far, no study investigated if such bacteria exist in terrestrial environments e....
2022-12-14 | MTBLS5841 | MetaboLights
TranscriptomicsVectorial secretion of interleukin-8 (IL-8 or CXCL8) mediates homeostatic effects on the intestinal epithelium via apically located CXCR1
CXCL8 is produced by many cell types including epithelial, endothelial, fibroblasts and macrophages in response to TLR recognition of microbe-associated molecular patterns (MAMPs) or inflammatory cytokines and recruits phagocytes from the vasculature to sites of infection via interaction with its co...
ORGANISM(S): Homo sapiens 
2014-06-28 | E-GEOD-30364 | biostudies-arrayexpress
TranscriptomicsREG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum
Objective: Reg3g has been proposed to have a protective role against infection due to its bactericidal effect on Gram-positive bacteria, but evidence from in vivo studies is lacking. Therefore we generated a Reg3g-/- mouse, to determine its role in intestinal homeostasis and protection against exper...
ORGANISM(S): Mus musculus 
2014-06-06 | E-GEOD-44409 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Arabidopsis expressing Cladosporium fulvum virulence protein Avr2
Heterologous expression of the fungal pathogen Cladosporium fulvum Avr2 in Arabidopsis plants. Experiment Overall Design: Samples used for microarray analyses were replicated three times in independent experiments and each replication consisted of 10 Avr2-expressing Arabidopsis plants and 10 Col-0 p...
ORGANISM(S): Arabidopsis thaliana 
2008-10-26 | E-GEOD-10801 | biostudies-arrayexpress
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