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UnknownComprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses.
Not available
S-EPMC11513043 | biostudies-literature
MetabolomicsComprehensive lipid analysis of green Arabica coffee beans by LC-HRMS/MS
Lipids play an important role in coffee bean development, coffee brew and in the effects of coffee on human health. They account for around 17% of the dry bean weight and encompass different classes and subclasses, mostly triacylglycerols (TAG) and a minor quantity of phospholipids (PL) and βN-alkan...
2021-11-19 | MTBLS1972 | MetaboLights
TranscriptomicsEpigenetic and transcriptional aberrations in human pluripotent stem cells reflect differences in reprogramming mechanisms [RNA-Seq]
Human pluripotent stem cells hold great potential for regenerative medicine, but available cell types have important limitations. While embryonic stem cells derived from fertilized embryos (IVF-ESCs) are considered the "gold standard" of pluripotency, they are allogeneic to potential recip...
ORGANISM(S): Homo sapiens 
2014-07-08 | E-GEOD-53094 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP_chip]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30204 | biostudies-arrayexpress
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
GenomicsDNA binding factors shape the mouse methylome at distal regulatory regions [ChIP-seq].
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-09 | E-GEOD-30203 | biostudies-arrayexpress
TranscriptomicsThe Snf1-Related Kinase, Hunk, Is Essential for Mammary Tumor Metastasis
We previously identified a novel SNF1/AMPK-related protein kinase, Hunk, from a mammary tumor arising in an MMTV-neu transgenic mouse. The function of this kinase is unknown. Using targeted deletion in mice, we now demonstrate that Hunk is required for the metastasis of c-myc-induced mammary tumors,...
ORGANISM(S): Mus musculus 
2009-12-31 | E-GEOD-14226 | biostudies-arrayexpress
TranscriptomicsDNA binding factors shape the mouse methylome at distal regulatory regions [RNA_seq]
To gain insights into the interplay between DNA methylation and gene regulation we generated a basepair resolution reference map of the mouse methylome in stem cells and neurons. High genome coverage allowed for a novel quantitative analysis of local methylation states, which identified Low Methylat...
ORGANISM(S): Mus musculus 
2011-12-22 | E-GEOD-30280 | biostudies-arrayexpress
UnknownCombining globally search for a regular expression and print matching lines with bibliographic monitoring of genomic database improves diagnosis.
Not available
S-EPMC10157399 | biostudies-literature
GenomicsNational Cancer Institute Genome-Wide Association Study of Renal Cell Carcinoma

The National Cancer Institute (NCI) genome-wide association study (GWAS) of renal cell carcinoma (RCC) was conducted to investigate common genetic variants associated with RCC risk. The GWAS includes 1,453 RCC cases and 3,531 controls of European background from 4 studies (3 cohort, 1 case-con...

phs000351.v1.p1 | EGA
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