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TranscriptomicsSystems biology analysis unravels complementary action of combined Rosuvastatin and Ezetimibe therapy
Transcriptomics analysis to understand both efficacy and side effects of a cholesterol lowering drug combination therapy based on biological pathways and molecular processes affected by each drug alone or in combination. We have treated ApoE*3Leiden mice, a humanized atherosclerosis model with a uni...
ORGANISM(S): Mus musculus 
2013-02-27 | E-GEOD-38688 | biostudies-arrayexpress
UnknownIncidence of small bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy.

Background and study aims

Lynch syndrome (LS) patients have an increased risk of small bowel cancer. The question is whether surveillance will lead to early detection of (pre)malignant lesions. We recently reported on prevalence of small bowel neoplasia (SBN) in LS patients as assessed by vi...
S-EPMC5500106 | biostudies-literature
UnknownPyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding.
Monoclonal antibodies are important modalities in the treatment of cancer. Post-translational modifications of proteins, such as glycosylation, can affect the binding affinity of therapeutic antibodies. Whether other PTMs modulate therapeutic antibody binding to different surface proteins is current...
S-EPMC12615796 | biostudies-literature
TranscriptomicsA systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone
Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone, whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treate...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-48977 | biostudies-arrayexpress
UnknownPhysical and mental health of breast cancer patients and survivors before and during successive SARS-CoV-2-infection waves.

Purpose

During the first SARS-CoV-2-infection wave, a deterioration in emotional well-being and increased need for mental health care were observed among patients treated or being treated for breast cancer. In this follow-up study, we assessed patient-reported quality of life (QoL), physical...
S-EPMC10072805 | biostudies-literature
UnknownHospitalising preterm infants in single family rooms versus open bay units: A systematic review and meta-analysis of impact on parents.

Background

Many parents develop stress-related symptoms and depression when their preterm infant is hospitalised in the neonatal intensive care unit (NICU) after birth. We reviewed the evidence of parent well-being with preterm infants hospitalised in single family rooms (SFRs) or in open ba...
S-EPMC7284081 | biostudies-literature
UnknownInflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study.
Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD). We hypothesized that MIS-C and KD might have commo...
S-EPMC9710748 | biostudies-literature
UnknownCommunication at work: A survey to explore the relationships between healthcare providers' communication competence and professional quality of life in neonatal care.

Objective

Providing medical care to preterm infants can be rewarding yet also stressful for healthcare providers in the neonatal care unit (NICU). While the impact of provider-parent communication on parent-related stress and satisfaction is widely accepted, little is known about the provide...
S-EPMC11437867 | biostudies-literature
TranscriptomicsSupervised Lowess normalization of comparative genome hybridization data: application to lactococcal strain comparisons.
Background Array-based comparative genome hybridization (aCGH) is commonly used to determine the genomic content of bacterial strains. In aCGH data, systematic errors are comparable to those occurring in transcriptome data. However, especially for microbes, an additional source of variation exists: ...
ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363 
2008-07-19 | E-GEOD-9039 | biostudies-arrayexpress
UnknownIs the generalizability of a developed artificial intelligence algorithm for COVID-19 on chest CT sufficient for clinical use? Results from the International Consortium for COVID-19 Imaging AI (ICOVAI).

Objectives

Only few published artificial intelligence (AI) studies for COVID-19 imaging have been externally validated. Assessing the generalizability of developed models is essential, especially when considering clinical implementation. We report the development of the International Consort...
S-EPMC9848031 | biostudies-literature
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