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TranscriptomicsChromosomal abberations and transcriptional characteristics linked to the pathogenesis of diffuse large b-cell lymphomas
We superimposed array comparative genomic hybridization (aCGH) data onto existing expression array profiles (GSE3892) to sift out the pivotal genes underlying the pathogenesis of a well defined series of diffuse large B-cell lymphomas (DLBCL). 280 gained and over-expressed genes were identified, loc...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-5138 | biostudies-arrayexpress
TranscriptomicsIdentification of a subgroup of head and neck cancers lacking numerical chromosomal aberrations
ABSTRACT Two major subgroups of head and neck squamous cell carcinomas (HNSCC) are currently distinguished based on etiology and pattern of genetic alterations; tumors with biologically active human papillomavirus (HPV) and tumors without. It is at present unclear whether additional genetically dist...
ORGANISM(S): Homo sapiens 
2009-03-11 | E-GEOD-11929 | biostudies-arrayexpress
TranscriptomicsLosses of chromosome 5q and 14q mark a subset of gastric cancers with good clinical outcome
Purpose: To improve clinical outcome of gastric cancer patients, most emphasis is on improving therapeutic regimens, including more extensive surgery as well as (neo)adjuvant chemotherapy. The present study set out to identify, based on DNA copy number profiling, subgroups of patients with different...
ORGANISM(S): Homo sapiens 
2012-05-09 | E-GEOD-26389 | biostudies-arrayexpress
TranscriptomicsHNSCC Cells: ctrl vs six tumour lethal miRNAs transfected
Some microRNAs have antiproliferative effects in cells and are believed to act as tumour suppressors. We used a retroviral human microRNA expression library to identify six microRNAs, miR-181a, miR-323, miR-326, miR-342, miR345 and miR-371, that induce antiproliferative effects in head and neck squa...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-34881 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and transcriptional profiling yields putative marker genes for cervical cancer
A better understanding of the consequences of recurrent (epi)genetic alterations that occur during cervical carcinogenesis is essential in the search for novel biomarkers. In this study we determined genome-wide expression profiles of 10 squamous cell carcinomas (SCCs), 5 adenocarcinomas (AdCAs) and...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-6473 | biostudies-arrayexpress
TranscriptomicsAltered microRNA expression associated with chromosomal and epigenetic changes contributes to cervical carcinogenesis
Little is known about the alterations in microRNA (miRNA) expression patterns during the consecutive stages of cervical cancer development and their association with chromosomal instability and epigenetic changes. We integrated miRNA expression profiles in normal cervical squamous epithelium, high-g...
ORGANISM(S): Homo sapiens 
2012-06-27 | E-GEOD-30656 | biostudies-arrayexpress
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