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TranscriptomicsEarly divergence of Th1 and Th2 transcriptomes involves a small core response and sets of transiently expressed genes
Helper T cells can adopt a number of different phenotypes. We performed microarray-assisted mRNA profiling on antigen-stimulated, TCR transgenic murine splenocytes that were cultured in the presence of cytokines. Transcriptome snapshots of Th cells differentiating into Th1 and Th2 phenotypes were o...
ORGANISM(S): Mus musculus 
2013-03-01 | E-MTAB-1475 | biostudies-arrayexpress
TranscriptomicscDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype
Mammary cancer is the most common type of cancer in female dogs with a lifetime risk of over 24% when dogs are not spayed. The elucidation of the complete canine genome opens new areas for development of cancer therapies. These should be tested first by in vitro models such as cell lines. However, t...
ORGANISM(S): Canis lupus familiaris 
2007-09-01 | E-GEOD-7659 | biostudies-arrayexpress
UnknownOutbreak of Salmonella Bovismorbificans associated with the consumption of uncooked ham products, the Netherlands, 2016 to 2017.
Not available
S-EPMC5765776 | biostudies-literature
UnknownFeasibility to infer accurate fibrinogen concentrations from thrombin generation, prothrombin time, or Reptilase time waveforms.
Not available
S-EPMC12753218 | biostudies-literature
TranscriptomicsDifferential effects of TNFalpha and IL1beta on FLS global gene expression profile
TNFalpha and IL1beta play a pathogenic role in rheumatoid arthritis. Both cytokines are known to activate cytokine and metalloproteinase secretion by synovial fibroblasts. In the present study, we wanted to investigate whether TNFalpha and IL1beta displayed differential effects on cultured Fibroblas...
ORGANISM(S): Homo sapiens 
2009-04-15 | E-GEOD-15615 | biostudies-arrayexpress
TranscriptomicsDC immunotherapy in HIV-1 infection induces a major blood transcriptome shift
Objective: This study aimed to evaluate the effect of dendritic cell (DC) vaccination against HIV-1 on host gene expression profiles. Design: Longitudinal PBMC samples were collected from participants of the DC-TRN trial for immunotherapy against HIV. Microarray-assisted gene expression profiling ...
ORGANISM(S): Homo sapiens 
2015-04-30 | E-MTAB-3296 | biostudies-arrayexpress
UnknownAirway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms.
Not available
S-EPMC10068516 | biostudies-literature
TranscriptomicsHigh titers and low fucosylation of early anti-SARS-CoV-2 IgG promote hyper-inflammation by anti-inflammatory macrophages (MIL10)
Patients diagnosed with coronavirus disease 2019 (COVID-19) mostly become critically ill around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early phase severe acu...
ORGANISM(S): Homo sapiens 
2021-04-30 | E-MTAB-10431 | biostudies-arrayexpress
UnknownAge and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS-CoV-2-Specific CD8<sup>+</sup> T Cell Responses.
Not available
S-EPMC11898545 | biostudies-literature
TranscriptomicsGene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML
Mononuclear cells from AML patients (n=46) were sorted into CD34+ and CD34- subfractions and genome-wide expression analysis was performed using Illumina BeadChip Arrays (HT12 v3). Of 2 AML samples only the CD34+ fraction could be analyzed. AML CD34+ and CD34- gene expression was compared to a large...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-30029 | biostudies-arrayexpress
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