Sort   by:  
 Page size 
TranscriptomicsGenome-wide blood transcriptional profiling in critically ill patients - MARS consortium
The host response in critically ill patients with sepsis, septic shock remains poorly defined. Considerable research has been conducted to accurately distinguish patients with sepsis from those with non-infectious causes of disease. Technological innovations have positioned systems biology at the fo...
ORGANISM(S): Homo sapiens 
2015-07-06 | E-GEOD-65682 | biostudies-arrayexpress
TranscriptomicsData expression in alveolar macrophages induced by lipopolysaccharide in humans
Rationale: Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated in the pathogenesis and/or severity of several lung diseases, including pneumonia, chronic obstructive pulmonary disease and asthma. Alveolar macrophages are the main resident leukocytes expos...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-40885 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression analysis of the whole blood leukocyte transcriptional response to endotoxin treatment
Several inflammatory diseases respond to TNFα inhibitors, implicating TNFα signaling in the pathogenesis of these conditions. Here, we set out to map the systemic genome-wide transcriptome influenced by TNFα release. We performed an intravenous endotoxin challenge in 16 healthy subjects, half of who...
ORGANISM(S): Homo sapiens 
2014-02-24 | E-GEOD-36177 | biostudies-arrayexpress
TranscriptomicsLung gene expression analysis of WT, Nlrp3-, Asc-deficient mice in Streptococcus pneumoniae D39 and ATCC6303 infection
Streptococcus (S.) pneumoniae is the most frequently isolated causative pathogen community-acquired pneumonia, a leading cause of mortality worldwide. We investigated the role of the inflammasome sensor NLRP3 and the inflammasome adapter ASC during S. pneumoniae pneumonia. Detailed analysis of the e...
ORGANISM(S): Mus musculus 
2014-11-27 | E-GEOD-42464 | biostudies-arrayexpress
Sort   by:  
 Page size