Genome-wide blood transcriptional profiling in critically ill patients - MARS consortium

ABSTRACT: The host response in critically ill patients with sepsis, septic shock remains poorly defined. Considerable research has been conducted to accurately distinguish patients with sepsis from those with non-infectious causes of disease. Technological innovations have positioned systems biology at the forefront of biomarker discovery. Analysis of the whole-blood leukocyte transcriptome enables the assessment of thousands of molecular signals beyond simply measuring several proteins in plasma, which for use as biomarkers is important since combinations of biomarkers likely provide more diagnostic accuracy than the measurement of single ones or a few. Evidence suggests that genome-wide transcriptional profiling of blood leukocytes can assist in differentiating between infection and non-infectious

ORGANISM(S): Homo sapiens

SUBMITTER: Brendon Scicluna 

PROVIDER: E-GEOD-65682 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress