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ProteomicsArylsulfamates inhibit colonic Bacteroides growth through lipid kinases and not sulfatases
Excessive degradation of the colonic mucin layer by Bacteroides within the human gut microbiota drives inflammatory bowel disease in mice. Bacterial carbohydrate sulfatases are key enzymes in gut colonization, as they are elevated in human inflammatory bowel disease and correlate with disease severi...
ORGANISM(S): Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) Bacteria 
2025-07-28 | PXD065411 | Pride
Sulfatase Bacteroides thetaiotaomicron Thermal proteome profiling Arylsulfamate 
ProteomicsDegradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin
Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence factors, including toxins, adhesins, and noncanonical factors such as the protease EatA. The first line ...
ORGANISM(S): Escherichia coli ETEC H10407 Homo sapiens (Human) 
2026-01-19 | PXD068558 | Pride
Mucus Mucin o-glycosylation Protease Etec 
ProteomicsMembrane proteomis profile along human colon
The colonic epithelium is a highly dynamic system important for regulation of ion and water homeostasis via absorption and secretion, and in maintaining a protective barrier between the outer milieu and the inside of our body. These processes are known to gradually change along the length of the col...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-07 | MSV000079561 | MassIVE
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