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MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
TranscriptomicsThe protein disulfide isomerase AGR2 is essential for the production of intestinal mucus
Protein disulfide isomerases (PDIs) aid protein folding and assembly by catalyzing formation and shuffling of cysteine disulfide bonds in the endoplasmic reticulum (ER). Many members of the PDI family are expressed in mammals but the roles of specific PDIs in vivo are poorly understood. A recent hom...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-12503 | biostudies-arrayexpress
ProteomicsLabel-free and targeted mass tandem (TMT-labelled) global proteomic analyses on mucus from the stomach, small and large intestine of pigLabel-free and targeted mass tandem (TMT-labelled) global proteomic analyses on mucus from the stomach, small and large intestine of pig
The gastrointestinal mucus is a hydrogel that lines the luminal side of the gastrointestinal epithelium, offering barrier protection from pathogens and lubrication of the intraluminal contents. These barrier properties likewise affect nutrients and drugs that need to penetrate the mucus to reach the...
ORGANISM(S): Sus scrofa (Pig) 
2022-03-07 | PXD029371 | Pride
Gastrointestinal Mucus Composition Healthy Porcine Pig 
TranscriptomicsMicrobiota facilitates dietary heme-induced epithelial hyperproliferation and hyperplasia by breaking the mucus barrier
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-40670 | biostudies-arrayexpress
ProteomicsMucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human endo- and ecto-cervix chips
Modulation of mucus production by the human ecto- and endo-cervical epithelium by steroid hormones and associated interactions with commensal microbiome play a central role in the physiology and pathophysiology of the female reproductive tract. However, most of our knowledge about these interactions...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-26 | MSV000091806 | MassIVE
ProteomicsLabel-free and targeted mass tandem (TMT-labelled) global proteomic analyses on mucus from the stomach, small and large intestine of a domestic and laboratory dogs
Gastrointestinal (GI) mucus is continuously secreted and lines the entire length of the GI tract. Essential for health, it keeps the noxious luminal content away from the epithelium and propels forward the digesta. The aim of our study was to characterize the composition and structures of mucus thro...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-03-07 | PXD029356 | Pride
Canine Gastrointestinal Mucus Composition Dog Healthy 
TranscriptomicsTranscription profiling of E. coli grown on minimal mucus or minimal glucose
E.coli grown on mucus vs. glucose in shaking cultures
ORGANISM(S): Escherichia coli 
2007-07-27 | E-MEXP-1177 | biostudies-arrayexpress
ProteomicsProteomics of cervical mucus in natural and stimulated cycle
Cervical mucus is a viscous fluid functioning as a uterine cervix plug. It is formed and produced by cervical glands located in the cervix. During ovulation, cervical mucus starts to become less viscous, which is a good window for non-invasive sampling. Our study focuses on the proteomic characteriz...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD037654 | Pride
Cervix Fluid Cancer Endometrioisis Proteomics Endometrium Receptivity Mucus Biomarker 
ProteomicsDecoding Octopus Mucus: Impact of Aquarium-Maintenance and Senescence on the Skin Mucus Proteome Profile of the Common Octopus (Octopus vulgaris)
This work investigates the comparison of protein profiles in the Octopus vulgaris skin mucus of wild, aquarium-maintained, and senescent specimens to identify potential welfare biomarkers, using tandem mass tag (TMT) in an Orbitrap Eclipse Tribrid mass spectrometer to create a reference dataset from...
ORGANISM(S): Octopus vulgaris 
2025-05-07 | PXD052915 | Pride
Wild Proteomics Mass spectrometry Bioactive peptides Octopus vulgaris Non-invasive methods Welfare Food Aquarium-maintained Senescent Skin mucus 
ProteomicsEffects of Experimental Terrestrialization on the Skin Mucus Proteome of African Lungfish (Protopterus dolloi), part 2
Animal mucosal barriers constantly interact with the external environment and this interaction is markedly different in aquatic and terrestrial environments. Transitioning from water to land was a critical step in vertebrate evolution but the immune adaptations that mucosal barriers such as the skin...
ORGANISM(S): Protopterus dolloi 
2018-10-19 | PXD008982 | Pride
Mucosal immunity  mucus  proteomics  terrestrialization  african lungfish  skin  lc-ms/ms 
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