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ProteomicsDistinct transcriptomic, proteomic and epigenetic stress-responses in dorsal and ventral hippocampus
The hippocampus - one of the most studied brain regions – is a key target of the stress response and vulnerable to the detrimental effects of stress. Although its intrinsic organization is highly conserved throughout its long dorsal-ventral axis, the dorsal hippocampus is linked to spatial navigatio...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-03 | PXD006781 | Pride
Mouse hippocampus ventral dorsal proteome swath-ms stress 
ProteomicsThe proteome and phosphoproteome of acute stress in the mouse hippocampus (addendum phosphoproteomics males vs females)
This is an addendum for PXD024829 that was produced in the revision process. These additional data investigate the effect of forced swim stress on the phosphoproteome of male vs female mice immediately after stress exposure
ORGANISM(S): Mus musculus (Mouse) 
2022-02-09 | PXD029903 | Pride
Hippocampus Phosphoproteome Female Mus musculus Acute stress Male 
ProteomicsThe proteome and phosphoproteome of acute stress in the mouse hippocampus
The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, little is known about the nature and dynamics of the underlying molecular cascades. We used a brief forced swim exposure to trigger a strong stress response in mice, which transiently increa...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-09 | PXD024829 | Pride
Mouse Hippocampus Phosphoproteome Acute stress Proteome 
Proteomicscompartmentalized protein expression in rat hippocampal neurons undergoing homeostatic plasticity
Synaptic scaling is a form of homeostatic plasticity which allows neurons to adjust their action potential firing rate in response to chronic alterations in neural activity. Synaptic scaling requires profound changes in gene expression, but the relative contribution of local and cell-wide mechanisms...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-09 | PXD020745 | Pride
Neurons Stimulation Homeostatic plasticity Hippocampus Rat Cellculture Ptx Dendrites 
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