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TranscriptomicsTranscription profiling of human NHEK cells response to 2mM N-Acetyl-L-cystein (NAC) treatment - 1,12, 24 hour time-series
NHEK cells were plated at a density of 8 x 10 000/cm2 and the cell cultures were grown for 24 hours before addition of 2 mM N-Acetyl-L-Cystein. RNA obtained from cultures grown for 1, 12 and 24 hrs after NAC treatment were compared to RNA from untreated cells at the corresponding time points. I.e 1...
ORGANISM(S): Homo sapiens 
2005-07-15 | E-MEXP-146 | biostudies-arrayexpress
MetabolomicsGNPS - Amycolatopsis Extracts
Non-targeted MS/MS of Amycolatopsis cellculture extracts
ORGANISM(S): Amycolatopsis (ncbitaxon:1813) 
2017-02-21 | MSV000080559 | GNPS
GenomicsIdentification of histone modifications in cardiomyocytes of conditional HDAC4 knockout mice
Histone Deacetylase 4 (HDAC4) is known to contribute to cardiac remodeling processes. We wanted to identify and compare different genome wide targets of HDAC4 to well described interaction partners and its functional consequences. Therefore, we used a model of adult cardiomyocytes isolated from HDAC...
ORGANISM(S): Mus musculus 
2021-09-15 | E-MTAB-7319 | biostudies-arrayexpress
GenomicsIdentification of CaMKII-dependent H3S28p target genes
To identify direct CaMKII-dependent downstream genes of H3S28p we used chromatin-immunoprecipitation followed by massive parallel DNA sequencing (ChIPseq) analysis of isolated adult murine cardiomyocytes from CamKII WT as well as from CaMKIIγ/CaMKIIδ double knockout (DKO) . DKO and WT cells were sub...
ORGANISM(S): Mus musculus 
2019-06-13 | E-MTAB-8011 | biostudies-arrayexpress
GenomicsIdentification of MEF2 binding sites in adult mouse ventricular myocytes
The experiment was designed to assess genome-wide binding sites of Myocyte Enhancer Factor 2 (MEF2) in adult mouse ventricular cardiomyocytes.
ORGANISM(S): Mus musculus 
2021-09-15 | E-MTAB-9146 | biostudies-arrayexpress
Proteomicscompartmentalized protein expression in rat hippocampal neurons undergoing homeostatic plasticity
Synaptic scaling is a form of homeostatic plasticity which allows neurons to adjust their action potential firing rate in response to chronic alterations in neural activity. Synaptic scaling requires profound changes in gene expression, but the relative contribution of local and cell-wide mechanisms...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-09 | PXD020745 | Pride
Neurons Stimulation Homeostatic plasticity Hippocampus Rat Cellculture Ptx Dendrites 
TranscriptomicsTranscription profiling of human colon carcinoma cells Caco-2 response to N-acetyl-L-cystein (10 mM) (1,12 and 24 hour time-series)
Caco-2 human colon carcinoma cells were seeded at a density of 9 x 10 000 cells/cm2 and the cell cultures were grown for 24 hours before addition of 10 mM N-Acetyl-L-Cystein. RNA obtained from cultures grown for 1, 12 and 24 hrs after NAC treatment were compared to RNA from untreated cells at the c...
ORGANISM(S): Homo sapiens 
2005-07-15 | E-MEXP-147 | biostudies-arrayexpress
TranscriptomicsGene analysis of intracellular and extracellular Streptococcus pyogenes in human macrophages
The objective of this study was to investigate which genes are important for Streptococcus pyogenes during intracellular survival in human macrophages. Streptococcus pyogenes is an important human pathogen, which has recently gained recognition as an intracellular microorganism during the course of ...
ORGANISM(S): Streptococcus pyogenes 
2011-09-14 | E-GEOD-32130 | biostudies-arrayexpress
TranscriptomicsmiRNA profile in colon cancer cell culture
The hypothesis that the onset and development of colorectal cancer result from the alteration of the close cooperation of mRNA-miRNA has gained increasing popularity. We performed a multifaceted enrichment analysis of hypernetworks, taking advantage of the simultaneous evaluation of transcriptome an...
ORGANISM(S): Homo sapiens 
2014-09-30 | E-MTAB-2704 | biostudies-arrayexpress
MetabolomicsWolbachia modulation of lipid metabolism in Aedes albopictus mosquito cells
Certain strains of the intracellular endosymbiont Wolbachia can strongly inhibit or block the transmission of viruses such as dengue by Aedes mosquitoes, and the mechanisms responsible are still not well understood. Direct infusion and liquid chromatography FT-ICR mass spectrometry based lipidomicse...
MTBLS210 | MetaboLights
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