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MetabolomicsBiosynthesis of polyamine–polyphosphate granules for colitis alleviation

Natural polyamines, such as spermidine and spermine, exert strong anti-inflammatory effects, but their therapeutic benefits are limited by rapid absorption in the small intestine, resulting in low colonic availability. In this study, engineered Citrobacter freundii overexpressing ppk1 (CPP) coul...

2026-01-07 | MTBLS13621 | MetaboLights
ProteomicsProteomics of P granules Z granules and Mutator foci in C.elegans
To examine the protein composition of germ granules subcompartments of C. elegans, while ensuring their physiological integrity, we utilized TurboID-based proximity biotin labeling techniques to idedtify the protein components of P granules, Z granules and Mutator foci in the germline of C.elegans.
ORGANISM(S): Caenorhabditis elegans 
2024-07-14 | PXD046498 | Pride
P granules z granules  mutator foci  proteomics c.elegans 
ProteomicsJiangu granules treated OVX rat cone bone 4D-LC-MS analysis
Postmenopausal osteoporosis (PMOP) is a disease with a high prevalence in postmenopausal women and is characterized by an imbalance in bone metabolism, reduced bone mass, and increased risk of fracture due to estrogen deficiency. Jiangu granules (JG) is a compound prescription used in traditional C...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-25 | PXD037316 | Pride
4d label-free quantitative proteomics Jiangu granules Ovx rats Postmenopausal osteoporotic 
UnknownProteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules.
Not available
S-EPMC3834823 | biostudies-literature
UnknownZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains.
Not available
S-EPMC1636418 | biostudies-literature
ProteomicsProteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection
Neuromelanin is a complex polymer pigment found primarily in the dopaminergic neurons of human substantia nigra. Neuromelanin pigment is stored in granules including a protein matrix and lipid droplets. Neuromelanin granules are yet only partially characterised regarding their structure and function...
ORGANISM(S): Homo sapiens (Human) 
2016-12-22 | PXD004987 | Pride
Laser microdissection Neuromelanin Substantia nigra Lc-ms/ms 
UnknownCanonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA-binding protein 1.
Not available
S-EPMC10561663 | biostudies-literature
ProteomicsCharacterization of the proteome of human blood platelet sercretory granules using gas-phase fractionation (GPF)
We performed an extensive qualitative characterization of the platelet granule proteome using subcellular fractionation followed by mass spectrometry analysis and functional annotation. Platelets were isolated from whole blood by centrifugation and their level of purity was tested by microscopic ins...
ORGANISM(S): Homo sapiens (Human) 
2014-03-06 | PXD000618 | Pride
Platelet Secretory granules Gpf4 
ProteomicsStress granules proteome composition
Analysis of stress granules in HeLa cells, after exposure to different stimuli. Granules were collected by a newly devised enrichment method, described in manuscript. Proteomics sample preparation of granules was carried out using the Single-pot, solid phase-enhanced sample preparation, SP3 method (...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-02 | MSV000090634 | MassIVE
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD033533 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
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