Dataset Information


RNA-Seq analysis of KLF3 knockout E14.5 TER119+ (erythroid) murine fetal liver cells

ABSTRACT: The aim of this study was to analyze the transcriptome of TER119+ fetal liver cells in the absence of the transcription factor KLF3 at murine embryonic day E14.5 Three wildtype (WT; Klf3+/+) and three knockout (KO; Klf3-/-) samples


ORGANISM(S): Mus musculus  

PROVIDER: E-GEOD-50554 | ExpressionAtlas | 2015-08-03

REPOSITORIES: ExpressionAtlas

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Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor.

Mak Ka Sin KS   Burdach Jon J   Norton Laura J LJ   Pearson Richard C M RC   Crossley Merlin M   Funnell Alister P W AP  

Genome biology 20140430 4

Retroviral elements are pervasively transcribed and dynamically regulated during development. While multiple histone- and DNA-modifying enzymes have broadly been associated with their global silencing, little is known about how the many diverse retroviral families are each selectively recognized.Here we show that the zinc finger protein Krüppel-like Factor 3 (KLF3) specifically silences transcription from the ORR1A0 long terminal repeat in murine fetal and adult erythroid cells. In the absence o  ...[more]

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