Transcriptomics

Dataset Information

61

Transcription profiling of mouse developing and mature Nrl -/- retina against wild type controls


ABSTRACT: The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod differentiation and plays a critical role in regulating gene expression. In the mouse retina, rods account for 97% of the photoreceptors; however, in the absence of Nrl (Nrl-/-), no rods are present and a concomitant increase in cones is observed. Using mouse GeneChips (Affymetrix), we have generated expression profiles of the wild-type and Nrl-/- retina at three time-points representing distinct stages of photoreceptor differentiation. Experiment Overall Design: Both the Nrl-/- mice and wild type controls were of a matched mixed genetic background (R1 and C57BL/6 strains).

REANALYSIS of: E-GEOD-8972

ORGANISM(S): Mus musculus  

PROVIDER: E-GEOD-8972 | ExpressionAtlas | 2014-08-16

REPOSITORIES: ExpressionAtlas

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Publications

Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl.

Yoshida Shigeo S   Mears Alan J AJ   Friedman James S JS   Carter Todd T   He Shirley S   Oh Edwin E   Jing Yuezhou Y   Farjo Rafal R   Fleury Gilles G   Barlow Carrolee C   Hero Alfred O AO   Swaroop Anand A  

Human molecular genetics 20040526 14


The rod photoreceptor-specific neural retina leucine zipper protein Nrl is essential for rod differentiation and plays a critical role in regulating gene expression. In the mouse retina, rods account for 97% of the photoreceptors; however, in the absence of Nrl (Nrl-/-), no rods are present and a concomitant increase in cones is observed. A functional all-cone mouse retina represents a unique opportunity to investigate, at the molecular level, differences between the two photoreceptor subtypes.  ...[more]

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