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Transcription profiling by array of human umbilical cord mesenchymal stem cells treated with inflammatory serum

ABSTRACT: Peripheral infusion of human umbilical cord mesenchymal stem cells (hUC-MSCs) can profoundly suppress the activation of c-Mos and remarkably improve hepatic histology, suppress the systemic inflammatory reaction, and promote animal survival in a large non-human primate model of acute liver failure (ALF). The mechanism through which hUC-MSCs inhibits c-Mos activation in vivo remains unclear. We hypothesized that hUC-MSCs can adaptively produce certain inhibitory cytokines in response to the pro-inflammatory microenvironment. To confirm this, we stimulated cultured hUC-MSCs with inflammatory monkey serum (serum isolated at day 1 following toxin challenge). After a 30-min stimulation, the cells were collected for microarray gene expression analysis. A whole human genome oligo microarray analysis was performed to reveal the altered gene expression profiles of the hUC-MSCs

REANALYSIS of: E-MTAB-4750

ORGANISM(S): Homo sapiens

PROVIDER: E-MTAB-4750 | ExpressionAtlas | 2016-05-19

REPOSITORIES: ExpressionAtlas

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