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Theinmozhi2018 - Mechanism of PD1 inhibiting TCR signaling in Tumor immune regulation


ABSTRACT: Its a Deterministic ODE model showcasing mechanism of PDL1 induced TCR and CD38 signalling inhibition. The model also contains the LCK activation and inactivation phenomenon dependent on the particular phosphorylation site. This model is relevant in immunotherapy.

SUBMITTER: Krishna Kumar Tiwari   

PROVIDER: BIOMD0000000724 | BioModels Database| 2018-12-05

REPOSITORIES: BioModels

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Publications

Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling.

Arulraj Theinmozhi T   Barik Debashis D  

PloS one 20181024 10


Programmed cell death-1 (PD-1) is an inhibitory immune checkpoint receptor that negatively regulates the functioning of T cell. Although the direct targets of PD-1 were not identified, its inhibitory action on the TCR signaling pathway was known much earlier. Recent experiments suggest that the PD-1 inhibits the TCR and CD28 signaling pathways at a very early stage ─ at the level of phosphorylation of the cytoplasmic domain of TCR and CD28 receptors. Here, we develop a mathematical model to inve  ...[more]

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