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Nikolaev2019 - Immunobiochemical reconstruction of influenza lung infection-melanoma skin cancer interactions

ABSTRACT: This is a mathematical mechanistic immunobiochemical model that incorporates T cell pathways that control programmed cell death protein 1 (PD-1) expression. A core component of the model is a kinetic motif, termed a PD-1 Double Incoherent Feed-Forward Loop (DIFFL), which reflects known interactions between IRF4, Blimp-1, and Bcl-6.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000865 | BioModels | 2019-11-18

REPOSITORIES: BioModels

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Immunobiochemical Reconstruction of Influenza Lung Infection-Melanoma Skin Cancer Interactions.

Nikolaev Evgeni V EV Zloza Andrew A Sontag Eduardo D ED

Frontiers in immunology 20190128

It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the infection, where they expressed high levels of inflammation-induced cell-activation blocker PD-1, and became incapable of migrating back to the tumor site. At the same time, co-infection virus-specific CD8+ T cells remained functional while the infection was cleared. It was also unexpectedly found ...[more]

PMID: 30745900

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