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Transcription profiling of Yersinia enterocolitica reveals YtxR acts as an overriding transcriptional off switch for the Ysc-Yop type 3 secretion system

ABSTRACT: Data is also available from http://bugs.sgul.ac.uk/E-BUGS-53

INSTRUMENT(S): Variable Atmosphere Incubator

ORGANISM(S): Yersinia enterocolitica

SUBMITTER:

PROVIDER: E-BUGS-53 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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YtxR acts as an overriding transcriptional off switch for the Yersinia enterocolitica Ysc-Yop type 3 secretion system.

Axler-DiPerte Grace L GL Hinchliffe Stewart J SJ Wren Brendan W BW Darwin Andrew J AJ

Journal of bacteriology 20081114 2

The Yersinia enterocolitica YtxR protein is a LysR-type transcriptional regulator that induces expression of the ytxAB locus, which encodes a putative ADP-ribosylating toxin. The ytxR and ytxAB genes are not closely linked in the Y. enterocolitica chromosome, and whereas ytxR is present in all sequenced Yersinia spp., the ytxAB locus is not. These observations suggested that there might be other YtxR-regulon members besides ytxAB and prompted us to investigate coregulated genes and gene products ...[more]

PMID: 19011024

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