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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of Mycobacterium bovis and Mycobacterium tuberculosis overexpressing overexpressing BCG3145 and Rv3124

ABSTRACT: Data is also available from BuG@Sbase

ORGANISM(S): Mycobacterium bovis

SUBMITTER:

PROVIDER: E-BUGS-93 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue.

Mendoza Lopez Pablo P Golby Paul P Wooff Esen E Garcia Javier Nunez JN Garcia Pelayo M Carmen MC Conlon Kevin K Gema Camacho Ana A Hewinson R Glyn RG Polaina Julio J Suárez García Antonio A Gordon Stephen V SV

Microbiology (Reading, England) 20100408 Pt 7

A number of single-nucleotide polymorphisms (SNPs) have been identified in the genome of Mycobacterium bovis BCG Pasteur compared with the sequenced strain M. bovis 2122/97. The functional consequences of many of these mutations remain to be described; however, mutations in genes encoding regulators may be particularly relevant to global phenotypic changes such as loss of virulence, since alteration of a regulator's function will affect the expression of a wide range of genes. One such SNP falls ...[more]

PMID: 20378651

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