Dataset Information


Transcription profiling of human bronchial epithelial cells stimulated with the commensal bacterium S. salivarius K12 of the pathogens S. aureus, P. aeruginosa, or S. enteritidis

ABSTRACT: Human bronchial epithelial cells (16HBE14O-) were stimulated with the commensal bacterium S. salivarius K12, or the pathogens S. aureus, P. aeruginosa, or S. enteritidis (subtype Typhimurium) for 1 hour.


ORGANISM(S): Homo sapiens

DISEASE(S): S enteritidis

SUBMITTER: Jennifer Gardy 

PROVIDER: E-FPMI-13 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis.

Cosseau Celine C   Devine Deirdre A DA   Dullaghan Edie E   Gardy Jennifer L JL   Chikatamarla Avinash A   Gellatly Shaan S   Yu Lorraine L LL   Pistolic Jelena J   Falsafi Reza R   Tagg John J   Hancock Robert E W RE  

Infection and immunity 20080714 9

Streptococcus salivarius is an early colonizer of human oral and nasopharyngeal epithelia, and strain K12 has reported probiotic effects. An emerging paradigm indicates that commensal bacteria downregulate immune responses through the action on NF-kappaB signaling pathways, but additional mechanisms underlying probiotic actions are not well understood. Our objective here was to identify host genes specifically targeted by K12 by comparing their responses with responses elicited by pathogens and  ...[more]

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