Characterization of the oxidative stress regulon of Campylobacter jejuni

ABSTRACT: Background: During gut colonization, the enteric pathogen C. jejuni has to surmount the toxic effects of reactive oxygen species produced by its own metabolism, by the host immune system and by the intestinal microflora. Elucidation of C. jejuni oxidative stress defense mechanisms is critical for understanding Campylobacter pathophysiology. Results: The mechanisms of oxidative stress defenses in Campylobacter jejuni were characterized by transcriptional profiling, genes mutagenesis, and phenotypic analysis. The transcriptome changes, in response to H2O2, cumene hydroperoxide, or menadione exposure, were found to be oxidant specific and revealed the differential expression of genes belonging to a variety of biological pathways, from the classical oxidative stress defense systems, to the

ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168

SUBMITTER: Alain Stintzi 

PROVIDER: E-GEOD-13126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress