Cohesin localisation along fission yeast chromosomes delineates conserved mechanisms of binding

ABSTRACT: Cohesin holds sister chromatids together to enable their accurate segregation in mitosis. How, and where, cohesin binds to chromosomes are still poorly understood, and recent genome-wide surveys have revealed an apparent disparity between its chromosomal association patterns in different organisms. Here, we present the high-resolution analysis of cohesin localisation along fission yeast chromosomes. This reveals that several determinants, thought specific for distinct organisms, come together to shape the overall distribution. Cohesin is detected at chromosomal loading sites, characterised by the cohesin loader Mis4/Ssl3, in regions of strong transcriptional activity. Cohesin also responds to transcription by downstream translocation and accumulation at convergent transcriptional terminato

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Christine Schmidt 

PROVIDER: E-GEOD-13517 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress