Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse lung from a strain overexpressing IL-10 under control of the macrophage-specific CD68 promoter (macIL-10tg mice) after Mycobacterium tuberculosis infection


ABSTRACT: The cytokine IL-10 deactivates macrophages and has been shown to impair resistance to mycobacterial infection. We have infected transgenic mice overexpressing IL-10 under control of the macrophage-specific CD68 promoter (macIL-10tg mice) with Mycobacterium tuberculosis by aerosol and found increased bacterial loads in the lungs of macIL-10tg mice. To identify programs of genes regulated by IL-10 and associated with increased mycobacterial replication, genome-wide expression analysis was performed. Experiment Overall Design: Impact of IL-10 pulmonary gene expression in mouse M. tuberculosis infection

ORGANISM(S): Mus musculus

SUBMITTER: Roland Lang 

PROVIDER: E-GEOD-14316 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2014-12-21 | E-GEOD-57124 | biostudies-arrayexpress
2013-06-28 | E-GEOD-48027 | biostudies-arrayexpress
2013-12-31 | E-GEOD-44848 | biostudies-arrayexpress
2014-09-01 | E-GEOD-58810 | biostudies-arrayexpress
2023-04-24 | PXD037843 | Pride
2016-12-02 | E-MTAB-5218 | biostudies-arrayexpress
2010-11-13 | E-GEOD-25313 | biostudies-arrayexpress
2010-06-05 | E-GEOD-8639 | biostudies-arrayexpress
2007-09-12 | E-TABM-312 | biostudies-arrayexpress
2022-02-17 | PXD029017 | Pride