Transcription profiling of mouse PPAR-apha knockouts reveals gender-specific gene repression of PPAR-alpha knockouts in liver and heart

ABSTRACT: Most metabolic studies are conducted in male animals; thus, the molecular mechanism controlling gender-specific pathways has been neglected, including sex-dependent responses to peroxisome proliferator-activated receptors (PPARs). Here we show that PPARalpha has broad female-dependent repressive actions on hepatic genes involved in steroid metabolism and inflammation. In males, this effect is reproduced by the administration of synthetic PPARalpha ligand. Using the steroid hydroxylase gene Cyp7b1 as a model, we elucidated the molecular mechanism of this PPARalpha-dependent repression. Initial sumoylation of the ligand-binding domain of PPARalpha triggers the interaction of PPARalpha with the GA-binding protein alpha bound to the target promoter. Histone deacetylase is then recruited, and h

ORGANISM(S): Mus musculus

SUBMITTER: Sylvain Pradervand 

PROVIDER: E-GEOD-14395 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress