Transcription profiling of mouse wild type or nmMLCK-/- animals treated with SB/VILI reveals non muscle myosin light chain kinase isoform is an attractive molecular target in acute inflammatory lung injury

ABSTRACT: Acute lung injury (ALI), a major cause of acute respiratory failure with high morbidity and mortality, isare characterized by significant pulmonary inflammation and both alveolar and vascular barriers dysfunction. In Pprior studies have highlighted the role of nonmuscle myosin light chain kinase (nmMLCK) as an essential element of inflammatory response with MYLK polymorphisms associated withwhich alters ALI susceptibility. In the present study we sought to further define nmMLCK in acute inflammatory syndromes and examined We examined nmMLCK as a molecular target involved in increase of lung epithelial and endothelial barrier permeability. We utilized in two muirine models of inflammatory lung injury: intratracheal administration of endotoxin/lipopolysaccharide (LPS, 2.5 mg/kg) and VILI (v

ORGANISM(S): Mus musculus

SUBMITTER: Yong Huang 

PROVIDER: E-GEOD-14525 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress