Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Patrick Brown
PROVIDER: E-GEOD-18889 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA.
Hendrickson David G DG Hogan Daniel J DJ McCullough Heather L HL Myers Jason W JW Herschlag Daniel D Ferrell James E JE Brown Patrick O PO
PLoS biology 20091110 11
MicroRNAs (miRNAs) regulate gene expression posttranscriptionally by interfering with a target mRNA's translation, stability, or both. We sought to dissect the respective contributions of translational inhibition and mRNA decay to microRNA regulation. We identified direct targets of a specific miRNA, miR-124, by virtue of their association with Argonaute proteins, core components of miRNA effector complexes, in response to miR-124 transfection in human tissue culture cells. In parallel, we asses ...[more]
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