Dissecting the transcriptional response to DNA damage in Helicobacter pylori.
Ontology highlight
ABSTRACT:
ORGANISM(S): Helicobacter pylori
SUBMITTER: Marion Dorer
PROVIDER: E-GEOD-19334 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
DNA damage triggers genetic exchange in Helicobacter pylori.
Dorer Marion S MS Fero Jutta J Salama Nina R NR
PLoS pathogens 20100729 7
Many organisms respond to DNA damage by inducing expression of DNA repair genes. We find that the human stomach pathogen Helicobacter pylori instead induces transcription and translation of natural competence genes, thus increasing transformation frequency. Transcription of a lysozyme-like protein that promotes DNA donation from intact cells is also induced. Exogenous DNA modulates the DNA damage response, as both recA and the ability to take up DNA are required for full induction of the respons ...[more]
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