Stromal gene expression in human esophageal cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: N Clemons
PROVIDER: E-GEOD-19632 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers.
Saadi Amel A Shannon Nicholas B NB Lao-Sirieix Pierre P O'Donovan Maria M Walker Elaine E Clemons Nicholas J NJ Hardwick James S JS Zhang Chunsheng C Das Madhumita M Save Vicki V Novelli Marco M Balkwill Frances F Fitzgerald Rebecca C RC
Proceedings of the National Academy of Sciences of the United States of America 20100113 5
The stromal compartment is increasingly recognized to play a role in cancer. However, its role in the transition from preinvasive to invasive disease is unknown. Most gastrointestinal tumors have clearly defined premalignant stages, and Barrett's esophagus (BE) is an ideal research model. Supervised clustering of gene expression profiles from microdissected stroma identified a gene signature that could distinguish between BE metaplasia, dysplasia, and esophageal adenocarcinoma (EAC). EAC patient ...[more]
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