Glucose uptake is required for glucose-stimulated transcriptional response in Saccharomyces cerevisiae

ABSTRACT: Saccharomyces cerevisiae developed elegant mechanisms to monitor nutrient availability and trigger adaptative responses to nutrient deficiency. Nutrient sensing requires close coordination of cell surface sensors with intracellular mechanisms. This yeast senses the presence of glucose by two modified hexose transporters, Rgt2 and Snf3 (regulating expression of genes encoding hexose transporters) and the G-protein coupled receptor Gpr1 (modulating Protein Kinase A (PKA) activity).. It has been difficult to differentiate between cellular responses mediated by cell surface and intracellular sensors, respectively. Using a strain that is devoid of glucose uptake, we show that the mere presence of glucose does not elicit any glucose-dependent transcriptional responses. This indicates that signal

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Goutham Vemuri 

PROVIDER: E-GEOD-20566 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress