Evolutionary conservation of nuclear lamina-genome interactions

ABSTRACT: Regulation of gene expression is highly conserved between vertebrates, yet the genomic binding patterns of transcription factors are poorly conserved, suggesting that other mechanisms may contribute. The spatial organization of chromosomes in the nucleus is known to affect gene activity, but it is unclear to what extent this organization is conserved in evolution. Genome-wide maps of nuclear lamina (NL) interactions show that human and mouse chromosomes have highly similar folding patterns inside the nucleus. Breaks in synteny are often located at transition points between NL interacting and intra-nuclear regions. Data were compared against data from Peric-Hupkes, Meuleman et al. (Molecular Cell, 2010). LaminB1-chromatin interactions were assayed in human ESCs and human HT1080 cells. Lami

ORGANISM(S): Homo sapiens

SUBMITTER: Bas van Steensel 

PROVIDER: E-GEOD-22428 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress