DamID profiling of neural transcription factor binding in Drosophila melanogaster embryos

ABSTRACT: Paper abstract: Neural stem cells must strike a balance between self-renewal and multipotency, and differentiation. Identification of the transcriptional networks regulating stem cell division is an essential step in understanding how this balance is achieved. We have shown that the homeodomain transcription factor, Prospero, acts to repress self-renewal and promote differentiation. Amongst its targets are three neural stem cell transcription factors, Asense, Deadpan and Snail, of which Asense and Deadpan are repressed by Prospero. Here we identify the targets of these three factors throughout the genome. We find a large overlap in their target genes, and indeed with the targets of Prospero, with 245 genomic loci bound by all factors. Many of the genes have been implicated in vertebrate st

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Tony Southall 

PROVIDER: E-GEOD-18270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress