Genomics

Dataset Information

0

DamID profiling of neural transcription factor binding in Drosophila melanogaster embryos


ABSTRACT: Paper abstract: Neural stem cells must strike a balance between self-renewal and multipotency, and differentiation. Identification of the transcriptional networks regulating stem cell division is an essential step in understanding how this balance is achieved. We have shown that the homeodomain transcription factor, Prospero, acts to repress self-renewal and promote differentiation. Amongst its targets are three neural stem cell transcription factors, Asense, Deadpan and Snail, of which Asense and Deadpan are repressed by Prospero. Here we identify the targets of these three factors throughout the genome. We find a large overlap in their target genes, and indeed with the targets of Prospero, with 245 genomic loci bound by all factors. Many of the genes have been implicated in vertebrate stem cell self-renewal, suggesting that this core set of genes is crucial in the switch between self-renewal and differentiation. We also show that multiply bound loci are enriched for genes previously linked to nervous system phenotypes, thereby providing a short-cut to identifying genes important for nervous system development.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE18270 | GEO | 2009/09/25

SECONDARY ACCESSION(S): PRJNA117941

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-18270 | biostudies-arrayexpress
| E-GEOD-18214 | biostudies-arrayexpress
2009-10-01 | GSE18214 | GEO
| E-GEOD-18213 | biostudies-arrayexpress
2009-10-01 | GSE18213 | GEO
2016-03-31 | PXD001994 | Pride
| E-GEOD-66252 | biostudies-arrayexpress
2019-11-25 | GSE138680 | GEO
2015-10-28 | GSE66252 | GEO
2015-10-28 | GSE66250 | GEO