Transcriptomic and nuclear architecture of immune cells after LPS-activation

ABSTRACT: Changes in the nuclear positioning of specific genes, depending on their expression status, have been observed in a large diversity of physiological processes. However, gene position is poorly documented in immune cells subjected to activation upon bacterial infection. Using the pig as a model organism, we focused our study on monocytes-derived macrophages and neutrophils, the first lines of defense against pathogens. We examine whether changes in gene expression due to LPS-activation imply genes repositioning in the nuclear space. A transcriptomic analysis was first performed to identify the genes differentially expressed and analyse the networks implicated during LPS-IFNγ activation in monocytes-derived macrophages. This allowed us to select 4 up-regulated (IL1β, IL8, CXCL10 and TNFα) a

ORGANISM(S): Sus scrofa

SUBMITTER: Pascal Martin 

PROVIDER: E-GEOD-25491 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress