Global transcriptomic response of serum-resistant Neisseria meningitidis

ABSTRACT: Neisseria meningitidis remains an important cause of septicemia and meningitis. One of its major virulence traits is its ability to avoid killing by human serum. In the present work, the effect of growth phase (exponential versus stationary) and growth medium (THB versus Catlin) on normal human serum (NHS) sensitivity was assessed on two N. meningitidis serogroup B strains (MC58 and M982). Both strains were found to be dramatically more resistant to 20% NHS killing at early exponential phase than at stationary phase (73-100% survival after 1 to 2 hours of growth compared to less than 10% survival after 7 hours of growth). This growth phase effect was detected only when a rich medium (THB) was used while no such effect was observed using Catlin medium. KDO (2-Keto-3-deoxyoctulosonic acid) a

ORGANISM(S): Neisseria meningitidis

SUBMITTER: Bachra Rokbi 

PROVIDER: E-GEOD-26078 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress