Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

ABSTRACT: In this study, we demonstrate that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from hippocampus and olfactory bulb. Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampus and olfactory bulb-derived neural stem cells. Our analysis indicates that the balance between Wnt3, which triggers the expression of insulin via NeuroD1 transcription factor, and IGFBP-4, which inhibits the original Wnt3 action, is regulated depending on the diabetic status. We also show that adult neural progenitors derived from diabetic animals retain the ability to give rise to insulin-producing cells and that grafting neuronal progenitors into the pancreas of diabetic animals reduces glucose levels. This study provide

ORGANISM(S): Rattus norvegicus

SUBMITTER: Makoto Asashima 

PROVIDER: E-GEOD-27956 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress