Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Downstream targets of let-60 Ras in Caenorhabditis elegans

ABSTRACT: In Caenorhabditis elegans, let-60 Ras controls many cellular processes, such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out terminal effector functions leading to morphological change. We have used DNA microarrays to identify 708 genes that change expression in response to activated let-60 Ras. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Computed

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Beatrice Romagnolo 

PROVIDER: E-GEOD-2974 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Downstream targets of let-60 Ras in Caenorhabditis elegans.

Romagnolo Béatrice B   Jiang Min M   Kiraly Moni M   Breton Carrie C   Begley Rebecca R   Wang John J   Lund James J   Kim Stuart K SK  

Developmental biology 20020701 1

In Caenorhabditis elegans, let-60 Ras controls many cellular processes, such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out terminal effector functions leading to morphological change. We have used DNA microarrays to identify 708 genes that change expression  ...[more]