Transcription profiling of human head and neck squamous cell carcinomas that are positive or negative for Human Papilloma Virus

ABSTRACT: Introduction: Human Papilloma Virus (HPV) is associated with a subset of head and neck squamous cell carcinoma (HNSCC), between 15% and 35% of HNSCC harboring HPV, almost exclusively of subtype 16. Demographic and exposure differences between HPV-positive (+) and negative (-) HNSCCs suggest that HPV(+) tumors may constitute a subclass with different biology, while clinical differences have also been observed. In this study, gene expression profiles of HPV(+) and (-) tumors were compared to further explore the biological effect of HPV in HNSCC. Methods: Thirty-six HNSCC tumors were analyzed for gene expression using Affymetrix Human 133U Plus 2.0 GeneChip and for HPV using consensus primers for HPV L1, E6 and E7 by PCR and RT-PCR. Results: Eight (22%) of 36 tumors were positive for HPV, all

ORGANISM(S): Homo sapiens

DISEASE(S): HPV positive

SUBMITTER: Christine Chung 

PROVIDER: E-GEOD-3292 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress