Comparison of Darinaparsin and Arsenic Trioxide effect on HI-LAPC-4, human prostatic cancer cell line

ABSTRACT: Darinaparsin (DPS) is an arsenic cytotoxin with a more favorable toxicity profile than the established anti-leukemic drug, arsenic trioxide (ATO). Here we report effects of DPS on a variety of solid tumor cell lines under normoxia as well as hypoxia, the latter an important characteristic of the tumor microenvironment. Using MTT and clonogenic assays, we demonstrated that DPS had potent cytotoxic activities under both normoxia and hypoxia, with IC50??s ~ 2- to 3-fold lower than ATO. Xenograft studies using tumor cell lines as well as patient-derived tumor tissues implanted under the renal capsule in mice confirmed the anti-tumor activity of DPS in vivo. DPS was also a more potent radiosensitizer under hypoxia than ATO in vitro, and sensitized solid tumors to radiation in vivo at doses that

ORGANISM(S): Homo sapiens

SUBMITTER: Junqiang Tian 

PROVIDER: E-GEOD-33001 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress